Barely Significant
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Differential effect of supercoiling on bacterial transcription in topological domains.

PLoS Comput Biol · 2025 · PMC12622846 · PMID 41218075

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possibly significantno p-value reported
However, a dependence on the DNA sequence is also expected and might be characterized in future studies (with possibly significant impact on the interplay of topoisomerase I with transcription initiation).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.