Exploring the temperature stability of CRISPR-Cas12b using molecular dynamics simulations.

Mol Syst Des Eng · 2026 · PMC12624333 · PMID 41262327

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a decreasing trendno p-value reported

Interestingly, SASA showed a decreasing trend at elevated temperatures for both WT and MT, with MT showing a slower decrease at the beginning, and a lower overall surface area at the end (Fig.

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a slight trendno p-value reported

The other three mutations to hydrophobic residues show a slight trend towards lower RMSF.

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