Exploring SARS-CoV-2 spike protein mutations through genetic algorithm-driven structural modeling.

Bioinform Adv · 2025 · PMC12627402 · PMID 41268478

Europe PMC DOI

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highly significantP = 2.36 × 10 −16actually significant

As shown in Table 2 , the DOPE score exhibited a highly significant decrease ( t -test P = 2.36 × 10 −16 ; Mann–Whitney P = .000183), confirming a progressive enhancement in model stability and conformational quality across generations.

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