Barely Significant
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Evaluating Circulating Tumor DNA Clearance as an Early Intermediate End Point Predicting Clinical Benefit in Metastatic Nonsquamous NSCLC After First-Line Chemoimmunotherapy.

JTO Clin Res Rep · 2025 · PMC12629878 · PMID 41278397

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highly significantno p-value reported
1 B ), where greater ctDNA reductions were consistently associated with lower HRs and highly significant p values, suggesting that even modest declines in ctDNA could have clinical relevance.

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