Integrative genomic analysis reveals causal relationships between breast mammary tissue gene expression and breast cancer risk using multi-method Mendelian randomization.

Discov Oncol · 2025 · PMC12630431 · PMID 41258624

Europe PMC DOI

hedged sentence

0.0000

closest p · 0.0× alpha

0.0000

boldest claim

The sentences

highly significantp = 5 × 10−8actually significant

The analysis reveals several highly significant genetic loci that surpass the genome-wide significance threshold ( p = 5 × 10−8, indicated by the red dashed line).

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