For instance, we observed that varying only one component of the aging media but maintaining the same genetic background and experimental setup—such as in ‘Gresham-L’ vs ‘Gresham-P’ and ‘Campos-NR’ vs ‘Campos-DR’ datasets—led to highly significant yet not fully correlated outcomes (ρ=0.11 and ρ =0.54, respectively).
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The core genetic drivers of chronological aging in yeast are universal regulators of longevity.
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