DNA methylation and immune regulation in osteoporosis: emerging epigenetic targets for drug discovery.

Front Pharmacol · 2025 · PMC12634355 · PMID 41282636

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a notable trendno p-value reported

Genome-wide association analysis indicates a notable trend of hypomethylation across the genome in trabecular bone tissue of OP patients, with critical bone metabolism genes (including RUNX2, SOST, and OPG) displaying distinct methylation modifications ( Delgado-Calle et al., 2013 ).

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