Cysteine-reactive covalent chloro-N-acetamide ligands induce ferroptosis mediated cell death.

We detected a highly significant induction of lipid peroxidation after PROTAC 2c treatment as well as after treatment with CCW16 alone, which was comparable with peroxidation levels after HP treatment, suggesting that CCW16 and PROTAC 2c were involved in the activation of lipid peroxidation (Fig. 5A ).

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