a decreasing trendp = 0.094
1B ), although Cd + DM had a decreasing trend for spare respiratory capacity (Cd + DM, p = 0.094) which suggests that some limitation may occur. 3.4 Alterations in citric acid cycle Treatment with Cd and DM, individually and in combination, produced changes in key metabolites of the citric acid cycle and associated metabolic pathways, with DM having a more profound overall impact ( Fig. 4 ).