Cross-cohort validation and cutpoint estimation of the Janssen plasma p-tau217+ assay in predominantly cognitively normal community studies.

Alzheimers Dement · 2025 · PMC12639401 · PMID 41273220

Europe PMC DOI

hedged sentences

0.0860

closest p · 1.7× alpha

0.0860

boldest claim

The sentences

marginally significantp = 0.086so close (0.05 < p ≤ 0.1)

As shown in Figure S2 , among the three cohorts, only the MYHAT‐NI cohort demonstrated a marginally significant elevation in p‐tau217+ levels in the impaired group, with a fold change of 1.38 (p = 0.086).

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marginal significanceno p-value reported

In univariate analyses, we observed a significant positive correlation between age and p‐tau217+ levels in both the MYHAT‐NI and CoBrA cohorts, with marginal significance in the HeartSCORE cohort.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.