Association of genotypes at single-nucleotide polymorphisms in IL-28B, TGF-β1, TP53, MTHFR and GSTP1 gene and their combinations with ischemic stroke: A case-control study.

IBRO Neurosci Rep · 2025 · PMC12639443 · PMID 41280133

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP < 0.001actually significant

Chi square test results revealed that the genotypic frequency varied highly significant (P < 0.001) when compared between Ischemic stroke patients and control group: Wild genotype (CC) was more common in cases while controls had more frequent polymorphic (TT) and heterozygous (CT) genotypes indicating that subjects wild genotype were more susceptible to develop Ischemic stroke.

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an increasing trendno p-value reported

There is an increasing trend to screen single nucleotide polymorphisms (SNPs) in genes as they are the disease modifiers that affect its severity and clinical course as susceptibility to disease development varies from person to person ( Kim, 2016 ).

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Association of genotypes at single-nucleotide polymorphisms in &lt;i&gt;IL-28B, TGF-β1&lt;/i&gt;, &lt;i&gt;TP53, MTHFR&lt;/i&gt; and &lt;i&gt;GSTP1&lt;/i&gt; gene and their combinations with ischemic stroke: A case-control study.

The sentences

Association of genotypes at single-nucleotide polymorphisms in <i>IL-28B, TGF-β1</i>, <i>TP53, MTHFR</i> and <i>GSTP1</i> gene and their combinations with ischemic stroke: A case-control study.