Conversely, when different hydrogels were co-incubated with bacterial suspensions or biofilm under light and non-light conditions, the Ca 2+ concentrations in the bacterial suspensions and biofilm of all hydrogel-treated groups showed a decreasing trend, with the TSCNPy 2+ -NPs-Light (+) group exhibiting the lowest Ca 2+ concentration ( Fig. 4 c and 4d–ii).
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Synergistic phototherapy and Ca<sup>2+</sup> consumption for combating biofilms in diabetic wounds <i>via</i> ion interference, physical disruption, and biological regulation.
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