Deficiency for MicroRNA-582 does not impact dilated cardiomyopathy or heart failure induced by pressure overload <i>in vivo</i>.

However, a nonsignificant trend toward attenuation of the induction of hypertrophic gene markers was observed in female double-knockout mice ( Figures 2Q,R ), whereas no differences were detected in male mice ( Figures 2L,M ). 3.5 TG-582 mice do not show a baseline cardiac phenotype We next examined the cardiac effects of miR-582 overexpression in TG-582 mice.

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