C1q limits cystoid edema by maintaining basal β-catenin-dependent signaling and blood-retina barrier function.

Grading the CE severity revealed that at T 0 + 6 months, CE scores in compound mutant mice tended to be higher than in single mutant mice but did not quite reach significance ( P = 0.0507, Figure 5B ).

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In addition, we observed a significant increase in the b/a ratio in C1qa -KO mice compared with WT mice at T 0 and a nonsignificant trend toward higher b/a ratios at the later time points, which may reflect developmental differences at the photoreceptor triad synapse in C1qa -KO mice ( 38 ).

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