Vitamin D and oral disease relationships: Insights from a bidirectional Mendelian randomization investigation.

Medicine (Baltimore) · 2025 · PMC12643689 · PMID 41305719

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hedged sentences

0.0885

closest p · 1.8× alpha

0.0885

boldest claim

The sentences

borderline significanceP = .0885so close (0.05 < p ≤ 0.1)

Although the IVW estimate for malignancies showed borderline significance (OR = 0.399, P = .0885), the consistent directional effects across complementary methods strengthen the plausibility of this association.

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marginally significantno p-value reported

MR analysis of various oral diseases as exposures and serum 25-hydroxyvitamin D levels as the outcome In bidirectional MR analyses evaluating oral disease-driven effects on serum 25-hydroxyvitamin D levels, only oral lichen planus (OLP) exhibited a marginally significant positive association with elevated serum 25-hydroxyvitamin D levels (OR = 1.010, 95% confidence interval [CI]: 1.000–1.020; Fig. 5 ).

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