M2 macrophages and tumor cells engage in a metabolic feedback loop to drive HCC progression.

Sci Rep · 2025 · PMC12644919 · PMID 41286064

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an increasing trendno p-value reported

Notably, M2-specific marker genes displayed an increasing trend from normal tissue to stage B (Fig. 2 L), highlighting the critical role of M2 macrophages in promoting tumor advancement.

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