Chronology of H3N2 human influenza virus surface glycoprotein adaptation from 1968 to 2019 reveals a surge of adaptation between 1997 and 2002.

Predicted NA N -linked glycosylation sites showed an increasing trend, from 7 on AI68 NA to 9 on SI87 to 12 on FU02 before plateauing, varying from 11 to 13 for the remaining viruses ( Fig. 5B ).

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