highly significantP < 0.0001
*, P < 0.05 was considered statistically significant, **, P < 0.01 was considered highly significant, and ****, P < 0.0001 was considered extremely significant.
*, P < 0.05 was considered statistically significant, **, P < 0.01 was considered highly significant, and ****, P < 0.0001 was considered extremely significant.