Barely Significant
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Global Burden of Depressive Disorders, 1990-2021, During the COVID-19 Pandemic and Projections to 2050: A Global Burden of Disease Study 2021.

Psychiatry Investig · 2025 · PMC12646708 · PMID 41276792

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an increasing trendno p-value reported
From 2010 to 2019, the global ASDR showed an increasing trend (2010: 584.98 [411.55 to 793.87]; 2019: 593.50 [413.34 to 810.07]; APC, 0.17 [0.16 to 0.19]), whereas the trends of ASDR in super-regions varied.

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a decreasing trendno p-value reported
Specifically, the ASDR showed a decreasing trend between 2004 and 2010, followed by a significant increase from 2019 onwards (2004: 622.18 [436.97 to 848.02]; 2010: 584.98 [411.55 to 793.87]; 2019: 593.50 [413.34 to 810.07]).

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.