On the other hand, several studies demonstrated that there was a highly significant inverse association between the prevalence of CRISPR-Cas system and drug resistance in carbapenem-resistant and ESBL-producing K. pneumoniae 29 , 95 , 100 .
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Association of the existence of CRISPR-Cas system and antimicrobial resistance in multi-drug resistant Klebsiella pneumoniae in Egypt.
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