Identification of novel type 1 and type 2 diabetes genes by co-localization of human islet eQTL and GWAS variants with colocRedRibbon.

coloc identifies a lead variant in a strong type 2 diabetes GWAS signal (red dot at the top, Figure 3 A) but overlooks an adjacent, highly significant—albeit weaker—signal ( Figure 3 A) that holds potential for a legitimate co-localization given the presence of a matching eQTL at the same chromosomal position ( Figure 3 A, bottom). coloc assumes under the H4 hypothesis that each trait has a single causal variant that is shared between traits.

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