highly significantp < 0.01
Statistical Analyses Data were processed in Microsoft Excel 2023 and GraphPad Prism software version 10 was used for all statistical analyses, including the calculation of serum and exosome concentrations, means, standard deviations (SDs), coefficient of determination (R 2 ), and p values (where * significant p < 0.05; ** highly significant p < 0.01; n.s. denotes non-significant).