The Conundrum of Medical Fracture Prevention in Chronic Kidney Disease-Summary of the Evidence and Pragmatic Clinical Guidance.

J Clin Med · 2025 · PMC12653605 · PMID 41303180

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borderline significantno p-value reported

However, a large observational study from Japan (n = 1032) showed borderline significant results for MACE compared to bisphosphonates (weighted 3-year RR 1.36 [95% CI, 0.99–1.87], weighted 3-year RD 8.2% [95% CI, −0.2% to 16.7%]) that need to be confirmed [ 135 ].

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marginally non-significantno p-value reported

(seven placebo-controlled trials, n = 7428, follow-up 12 months) was marginally non-significant with a HR of overall fracture risk reduction with ibandronate vs. placebo of 0.78 (95% CI, 0.746–1.018) [ 87 ].

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