Prevalence of Down Syndrome in Croatia in the Period from 2014 to 2024.

In contrast, analysis of the number of live-born children with Down syndrome relative to the total number of live births over the same period demonstrated a decreasing trend, with an estimated APC of −0.93% (95% CI: −4.1 to 2.2) ( Figure 2 ).

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These data suggest that Croatia’s DS prevalence among live births aligns with that of European Union countries, while the overall DS prevalence in the population shows an increasing trend consistent with international epidemiological research [ 11 ].

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