This raises a key question: does elevated choline intake improve DHA status in the mother and fetus during pregnancy by increasing PEMT activity? In a randomized controlled trial of 30 pregnant women, supplementation with 550 mg of choline and 200 mg DHA per day from 12 to 16 weeks of gestation until delivery significantly increased maternal plasma phosphatidylcholine–DHA and plasma DHA concentrations at delivery in addition to a positive trend on newborn biomarkers of DHA status [ 24 ].
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Future Directions in Choline: From Neurodevelopment to Cardiometabolic Health.
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