Short-Chain Fatty Acids and Colorectal Cancer: A Systematic Review and Integrative Bayesian Meta-Analysis of Microbiome-Metabolome Interactions and Intervention Efficacy.

The interaction term of “SCFA × ethnicity” was significant ( p = 0.02): the OR for the association between total SCFAs and CRC risk was 0.71 (95% CrI: 0.58–0.85) in Europeans, 0.86 (95% CrI: 0.73–1.01, marginally significant) in Asians, and African Americans had the lowest fecal SCFA levels (2.1 ± 0.8 mmol/L) and the highest CRC risk (OR = 0.92, 95% CrI: 0.70–1.21, with a wide confidence interval due to sample size limitation) (see Figure 2 for the Bayesian multi-dimensional stratified forest plot of the association between SCFAs and CRC/A-CRA risks).

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