Large-scale meta-analysis and precision functional assays identify FANCM regions in which PTVs confer different risks for ER-negative and triple-negative breast cancer.

Breast · 2026 · PMC12657754 · PMID 41223770

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an increasing trendno p-value reported

Accordingly, it is noteworthy that the ORs found for PTVs upstream of AA 670 in overall breast cancer, ER-neg and TN cases showed an increasing trend, suggesting a potential true association that requires further validation.

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