Large-scale multi-trait genome-wide analysis for inflammatory bowel disease reveals new insights into its molecular mechanisms and emphasizes the roles of systemic immune regulation.

In addition, we found evidence of high GNA12 expression in multiple sets of colorectal RNA-seq data ( GSE107593 : P = 7.48 × 10 −9 , LogFC = 0.42; GSE117993 : P = 6.76 × 10 −7 , LogFC = 0.27; GSE166925 : P = 1.09 × 10 −3 , LogFC = 0.52) and suggested an elevated trend in myeloid cells ( GSE162335 : P = 3.71 × 10 −13 , LogFC = 0.42).

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