CD8<sup>+</sup> T cells mediate the impact of gut dysbiosis and short-chain fatty acid deficiency on accelerated arthritis progression in collagen-induced arthritis mice.

( Figures 3A, C ) ( Supplementary Table 3A ) No significant differences were detected in immune cell populations in Peyer’s patches (PPs); ( Supplementary Table 3B ) however, T cells, B cells, NK cells, and CD8 + T cells showed an increasing trend, while CD4 + T cells showed a decreasing trend ( Figure 3A ).

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( Supplementary Tables 2C, D ) However, distinct distribution patterns were noted: CD11b + cDC2 was the dominant subset in PB, whereas both CD8α + cDC1 and CD11b + cDC2 were present in SP, although the ratio of CD8α + cDC1 to CD11b + cDC2 showed a decreasing trend ( Figure 2B ). 3.2.2.

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