NAT10-mediated lipid metabolic reprogramming drives EGFR-TKI resistance in non-small cell lung cancer via ac4C-dependent mRNA stabilization.

Exp Hematol Oncol · 2025 · PMC12661735 · PMID 41310903

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Introduction Non-small cell lung cancer (NSCLC) is a highly significant contributor to cancer-related mortality worldwide, accounting for a substantial proportion of all cancer deaths [ 1 , 2 ].

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