Mapping key mitochondrial genes in Alzheimer's disease through human tissue and iPSC derived neurons.

We developed a random forest model to assess the significance of these 14 dysregulated genes in AD, and the average AUC for 5-fold cross-validation was 0.93 (95% CI: 0.89–0.96) This suggests that this gene set is highly significant in differentiating AD patients from healthy controls and represents a complex regulatory program that is triggered in AD neurons under oxidative stress.

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