LINE-1 hypomethylation in cell-free DNA of high-grade glioma patients correlates with tissue levels and is associated with reduced DNMT1 and H4K20me3 expression.

Neurotherapeutics · 2025 · PMC12664440 · PMID 41006121

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marginal significanceno p-value reported

Regarding IDH1-R132H status, only the H3K9me3 H -score was significantly positively correlated with the presence of IDH1-R132H mutation (r = 0.486, p = 0.002) while cfLINE-1 methylation levels exhibited only marginal significance (r = 0.315, p = 0.058, Table 3 ).

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