Plasma p-tau<sub>217</sub> correlates strongly with cerebrospinal fluid Aβ<sub>42</sub> and increases over a ten-year period in amyloid-positive, non-demented very old men.

J Alzheimers Dis · 2025 · PMC12664933 · PMID 41160459

Europe PMC DOI

hedged sentences

0.0070

closest p · 0.1× alpha

0.0580

boldest claim

The sentences

an increasing trendp = 0.007actually significant

There was an increasing trend in the Aβ-positive group (B = 0.137, 95% CI = 0.039–0.235, p = 0.007), whereas levels remained unchanged over time in the Aβ-negative group ( p = 0.302).

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of borderline significancep = 0.058so close (0.05 < p ≤ 0.1)

The correlations of plasma p-tau 217 with CSF p-tau 181 concentration were of borderline significance at U-5 and U-6 (Spearman ρ : rho = 0.33, p = 0.058; rho = 0.33, p = 0.051) but did not exist at U-7 (Spearman ρ : rho = 0.20, p = 0.412), ( Supplemental Figure 1a-(c) ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Plasma p-tau&lt;sub&gt;217&lt;/sub&gt; correlates strongly with cerebrospinal fluid Aβ&lt;sub&gt;42&lt;/sub&gt; and increases over a ten-year period in amyloid-positive, non-demented very old men.

The sentences

Plasma p-tau<sub>217</sub> correlates strongly with cerebrospinal fluid Aβ<sub>42</sub> and increases over a ten-year period in amyloid-positive, non-demented very old men.