Metabolic profiling of prebiotic, probiotic, and synbiotic supplements in a canine colonic fermentation model: a pilot feasibility study reveals distinct and complementary effects.

For instance, the co-supplementation M + P showed a numerical trend toward mitigating the acetate reduction observed with probiotic P supplementation alone and resulted in distinct metabolic fingerprints in the distal colon, specifically altered abundance patterns of 1,603 metabolic features (m/z signals) as detected by LA-REIMS analysis, with valid OPLS-DA model differentiation (Q 2 (Y) ≥ 0.5) compared to controls.

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An observed trend toward increased ammonium and branched SCFA levels in the distal colon upon supplementation with any test product warrants careful consideration and represents an important limitation of this pilot study.

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