Genome-Wide Blood DNA Methylation Profiling in Birch Pollen Allergic Patients Undergoing Allergen-Specific Immunotherapy.

Additionally, a second hypermethylated CpG cg22336863 with β > 0.045 was found upstream of the transcription start site of actin‐binding Rho‐activating protein ( ABRA ), with an FDR‐adjusted p ‐value of 0.068, indicating a borderline significance that might reach statistical significance with a larger sample size (Table 2 ; Table S2 ; Figure S3 ).

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Finally, albeit only barely significant, cg22336863 ( ABRA ) showed hypermethylation, along with hypomethylation of several DMPs within the HLA gene complex.

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