The observed differences for PI(4,5)P 2 -treated cells compared to mock- and PS-treated cells were statistically highly significant, demonstrating the specific effect of the disruption of PI(4,5)P 2 transbilayer asymmetry on FGF2 membrane translocation to cell surfaces.
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Plasma membrane transbilayer asymmetry of PI(4,5)P<sub>2</sub> drives unconventional secretion of Fibroblast Growth Factor 2.
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