extremely significantp < 0.001
The strength of statistical significance was defined using the following thresholding system: ns (Not significant): p ≥ 0.05, * (Significant): 0.01< p < 0.05, ** (Very significant) 0.001< p < 0.01, *** (Extremely significant) 0.0001< p < 0.001, **** (extremely significant) p < 0.0001.