Analysis of prognostic factors influencing brain metastasis in EGFR-mutant lung adenocarcinoma and comparison of prognostic assessment models.

Oncol Lett · 2026 · PMC12670208 · PMID 41340876

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highly significantno p-value reported

The results confirmed that the three key independent prognostic factors: KPS <80 (HR, 2.706; 95% CI, 1.825–4.012; P<0.001), presence of extracranial metastasis (HR, 2.296; 95% CI, 1.543–3.418; P<0.001) and use of first-/second-generation EGFR-TKIs (HR, 7.155; 95% CI, 4.950–10.344; P<0.001) remained highly significant, with minimal change in their HRs ( Table II ).

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