While this affinity is slightly lower than that of specific synthetic inhibitors like Stattic (ΔG ≈ − 8.5 to − 9.5kcal/mol), it remains highly significant for a natural compound and supports a multi-target mechanism.
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Ferulic acid-loaded chitosan nanoparticles enhance radiotherapy efficacy via STAT3 suppression and caspase-8/p53 activation in Ehrlich ascites carcinoma.
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