23 While intrahepatic rTregs also show a decreasing trend, this difference lacks statistical significance in human studies, likely due to limited sample size. 23 Mirroring human findings, animal models of MASLD consistently demonstrate a reduction in hepatic Treg numbers. 40 , 41 Functional studies solidify the pathogenic consequence of Treg loss, as depl
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Dual roles of T cells in metabolic dysfunction-associated steatohepatitis pathogenesis and liver fibrosis: From inflammation to therapeutic targets.
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