Hyperfiltration and Metabolism Before and After a Low-Calorie, Pre-Gastric Bypass Surgery Diet: Significance for Concentrations of Hydrophilic and Lipophilic Drugs.

Indeed, when we plotted the concentration after the low‐calorie diet, divided by the concentration before the low‐calorie diet, henceforth called “post‐/pre‐diet ratio,” for each drug versus its distribution coefficient (logD; a measure of the lipophilicity of a substance, defined as the logarithm of the partitioning ratio between octanol and water), we found a highly significant negative correlation.

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