Renal and hepatic function is preserved following inducible knockout of kynurenine pathway enzymes KMO or QPRT in adult mice.

PLoS One · 2025 · PMC12677463 · PMID 41343438

Europe PMC DOI

hedged sentence

0.0770

closest p · 1.5× alpha

0.0770

boldest claim

The sentences

a trend towards significancep = 0.077so close (0.05 < p ≤ 0.1)

While this elevation only showed a trend towards significance (p = 0.077) this is likely the result of the large variability in KYNA levels in the 5 week post-tamoxifen cohort, but even the lowest KYNA concentration in this group was ~ 6.5-fold higher than the highest concentration in the control cohort.

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