highly significantP < 0.05
Statistical significance was determined using a One-way or Two-way ANOVA test with P < 0.001 considered extremely significant (***), P < 0.01 highly significant (**), and P < 0.05 statistically significant (*). mRNA expression, as measured by RT-qPCR, was normalized to the control cell expression, and the data represent the average of two biological replicates, each with corresponding duplicates.