Barely Significant
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Characteristics of Extremely Preterm Infants Undergoing Procedural Closure of Patent Ductus Arteriosus: A Retrospective Cohort Study.

Int J Pediatr · 2025 · PMC12680452 · PMID 41357829

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a decreasing trendno p-value reported
While the number of infants undergoing TCDC is increasing, there is a decreasing trend in the total number of surgical PDA closures.

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an increasing trendno p-value reported
This comprehensive review also demonstrates that in preterm infants born at ≤ 26 weeks and birth weight < 1000 g who experience hsPDA requiring mechanical ventilation, there is an increasing trend toward TCDC compared with surgical ligation, with an overall reduction in interventional PDA closure from 2007 to 2021 [ 15 ].

also in 28,909 other papers

The gestational age, weight, and feeding status prior to procedural closure of the PDA are marginally statistically significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.