Clinical Outcomes Following Discordance Between Fractional Flow Reserve and Instantaneous Wave-Free Ratio in Deferred Coronary Lesions: A Systematic Review and Meta-Analysis.

Rev Cardiovasc Med · 2025 · PMC12680999 · PMID 41356313

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a statistical trendno p-value reported

According to the DEFINE-FLAIR [ 5 ] and iFR-SWEDEHEART [ 6 ] trials, iFR-guided management was shown to be non-inferior to FFR-guided management based on the 12-month analysis, albeit a pooled meta-analysis of these two trials regarding death and myocardial infarction showed a statistical trend for higher rate of death and myocardial infarction in the iFR-guided management group [ 44 ].

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