Barely Significant
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Shared metabolomic signatures for prognostic precision across brain injuries.

Brain Spine · 2025 · PMC12682153 · PMID 41362357

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hedged sentences
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closest p · 2.0× alpha
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boldest claim

The sentences

a trend towards significancep < 0.1so close (0.05 < p ≤ 0.1)
Lactic acid showed a trend towards significance (p < 0.1, FDR-corrected).

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an increasing trendno p-value reported
Additionally, phospholipid levels showed an increasing trend in TBI patients ( Thomas et al., 2022 ).

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a decreasing trendno p-value reported
In cases of TBI, significant alterations have been observed in the metabolism of branched-chain amino acids (BCAAs), with most related metabolites predominantly showing a decreasing trend; however, some studies have reported contradictory results ( Orešič et al., 2016 ; Jeter et al., 2013 ).

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