Risk of Cardiovascular Disease With Co-Occurring Covert Brain Infarction and Unrecognized Myocardial Infarction.

In the fully adjusted models, we found a significant interaction between CBI and UMI on an additive scale (relative excess risk due to interaction, 3.2 [95% CI, 0.2–8.3]), and a nonsignificant trend for interaction on a multiplicative scale (HR interaction term, 2.0 [95% CI, 0.8–5.2]; P interaction =0.16).

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Schoenfeld residuals in model 3 for ASCVD risk were marginally significant, but the plots of the β coefficients over time suggested only minimal violation of the proportional hazards assumption (Figure S1 ).

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