Prenatal alcohol exposure promotes nerve injury-induced pathological pain following morphine treatment via NLRP3-mediated peripheral and central proinflammatory immune actions.

Brain Behav Immun · 2025 · PMC12684907 · PMID 40628342

Europe PMC DOI

hedged sentence

0.0700

closest p · 1.4× alpha

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boldest claim

The sentences

a trend toward significancep = 0.07so close (0.05 < p ≤ 0.1)

In females, NLRP3 mRNA was also elevated in allodynic PAE + morphine + vehicle mice compared to PAE + vehicle + vehicle controls (## p = 0.004), and there was a trend toward significance when compared to sac + morphine–treated mice (p = 0.07).

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