an increasing trendp < 0.001
The overall prevalence (per 100,000 persons) also showed an increasing trend, from 3065.76 (95% CI: 3051.68–3079.88) to 6296.38 (95% CI: 6277.02–6315.78), with an AAPC of 6.69% (95% CI: 6.45–7.03; p < 0.001) ( Fig. 1 a, Table 3 , Supplementary Table S2 ).