For data collected at 25 °C, there is an increasing trend up to the year 2000, and then the number of entries declined gradually in conjunction with the marked increase in cryo-data sets (Fig. 2 a and SI Fig. 1 ); however, it is still significantly more in number than those obtained at ≥ 37 °C (Fig. 3 ).
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Macromolecular crystallography for mammalian body temperature in support of molecular biophysics methods.
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